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VLP-PEG Conjugation Service

CD BioSciences is a global leader in providing custom services with advanced facilities and experienced scientists dedicated to helping each client develop chimeric virus-like particles (cVLPs) by chemically conjugating PEG to VLPs. we are happy to meet your requirements for developing vaccines, nanomaterials and diagnostic reagents based on VLPs.

Overview of PEG and PEGylation

Polyethylene glycol (PEG), also known as polyethylene oxide (PEO) or polyoxymethylene (POE), is an oligomer or polymer of ethylene oxide. PEGylation refers to the use of bioconjugation to link two molecules, one of which is a biomolecule and the other is a PEG.

PEG

When used to coat nanocarriers, PEG can enhance the biocompatibility, hydrophilicity, stability and biodegradability of nanocarriers. Although many alternatives to PEG such as sodium alginate, dextran and polyoxymethylene ethers have been developed as biocompatible polymers, PEG is still used as the polymer of choice. PEG is considered a non-degradable biomolecule but can be readily excreted through the kidneys. PEG is considered one of the best biocompatible polymers with the following advantages.

Advantages of PEG
High Solubility PEG has high solubility in aqueous media and organic solvents.	"Stealth Property" PEG inhibits its absorption by the reticuloendothelial system by reducing its interaction with blood components.
Ease of Chemical Modification PEG can be combined with almost all nanoparticle devices.	Stabilized Nanoparticles Because PEG is neutral, it can stabilize nanoparticles in complex and high ionic strength media.
Reduced Drug Toxicity PEG can reduce drug toxicity by increasing the lifetime of the "drug-carrier" combination to reduce the dose administered.	Additional Advantages Protects the conjugate surface from aggregation, opsonization, phagocytosis and prolongs the systemic circulation of nanoparticles.

Therefore, PEG is the most used polymer in biomedical fields such as drug delivery, targeting and imaging, and is the only polymer therapeutic agent that is marketed and approved for use with different drugs. PEG holds great promise in the development of current therapeutic and biomedical applications.

CPMV is coupled to PEG by chemical conjugation. (Steinmetz NF, et al., 2009)

Advantages of PEGylation

PEGylation is an effective strategy for reducing bispecific interactions of pharmaceuticals for the delivery of proteins and drugs, and PEGylation is increasingly being used for pharmaceutical and other biomedical applications. The advantages of PEGylation are as follows.

PEGylation can effectively reduce or block bispecific interactions between proteins or nanomaterials and cells or tissues.
When drugs such as liposomes, therapeutic proteins, dendrimers and other nanomaterials undergo PEGylation they can effectively improve water solubility and stability, improve pharmacokinetics, reduce renal clearance and decrease immunogenicity, etc.
In addition, the pharmacokinetics and toxicity of bioactive molecules are often strongly influenced by PEGylation.

Our Services

CD BioSciences offers chemical conjugation methods for VLPs PEGylation. If you are interested in our services, you can contact us directly, we are glad to hear from you and look forward to working with you.

Process of Our Service

Of course, CD BioSciences also offer you other services regarding our technology platform, including different plants to construct VLPs, VLPs purification, VLPs characterization assay, etc.

Reference

Steinmetz N.F.; Manchester, M. PEGylated viral nanoparticles for biomedicine: the impact of PEG chain length on VNP cell interactions in vitro and ex vivo. Biomacromolecules. 2009,4:784-792.

VLP-PEG Conjugation Service