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Acidic Amino Acids-based VLP Modification Service

Acidic Amino Acids-based VLP Modification Service

CD BioSciences is a leading global provider of custom services, working closely with clients and experts to modify virus-like particles (VLPs) by genetic fusion and chemical conjugation methods to aid in vaccine, nanomaterial, and diagnostic reagent development. Our experienced scientists are focused on a sophisticated VLPlantTM platform and are happy to meet the specific requirements of each client, providing the most appropriate solution to deliver high quality and on-time results in the shortest possible time.

Aspartate- or Glutamate-based Modification for cVLP Production

Overview of Acidic Amino Acids-based VLP Modification

Amino acids are biologically important organic compounds consisting of amino (-NH2) and carboxyl (-COOH) functional groups, and side chains attached to each amino acid. Amino acids are the basic units that constitute proteins, which endow proteins with specific molecular structure and form, and enable their molecules to have biochemical activity. Acidic amino acids, which are amino acids containing two carboxyl groups and one amino group, are mainly glutamate and aspartate.

  • Aspartate- or Glutamate-based VLPs Modifications
    The chemical conjugation method for constructing cVLPs based on aspartate and glutamate modifications differs from the modification methods involving cysteine and lysine. First, aspartic and glutamic must be activated with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC) because only after activation can their carboxyl groups react with n-hydroxysuccinimide (NHS) to form NHS esters. The carboxylic acid side chain can then form a stable amide bond with a ligand having a primary amino acid. This method is mainly used to embed peptides or fluorescent probes into VLPs to form cVLPs.


Aspartate is used in medicine to treat heart disease, as a liver function enhancer, detoxification agent, etc.


Glutamate contains two carboxyl groups and is involved in many important chemical reactions in plants, animals and microorganisms.

Our Services

As the world's leading custom service provider, CD BioSciences provides customers with VLP modification services based on acidic amino acids-modified chemical conjugation methods. If you are interested in our services, you can contact us for more details., we are happy to hear from you and look forward to working with you.

Why Choose CD BioSciences

Why Choose CD BioSciences

  • Experienced
    As a leading global custom service provider, CD BioSciences has long provided its global clients with services to construct cVLPs by chemical conjugation methods (based on cysteine and lysine modifications, etc.) and is adept at solving difficulties and challenges encountered during the experimental process.
  • Flexible
    Throughout the service period, from project consultation to delivery of results, we are in constant contact with our clients, helping them discuss problems encountered during experiments with our experienced scientists and updating solutions in real time to meet their needs.
  • High Quality
    As a leading global custom service provider dedicated to delivering highly customized and integrated solutions with the best quality, we have the ability and confidence to employ the best experimental solutions to meet your needs for fast and accurate construction of cVLPs.

In addition, we also provide different plants for the construction of VLPs, VLP purification and VLP characterization services. If you are interested in our services, you can contact us directly, we are happy to hear from you and look forward to working with you.

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