Cat. No. CIA-11350
CAS No. 57046-73-8
Key Features and Details
Product Size
Online Inquiry| Product Overview | |
|---|---|
| Activity | MKLP-2 inhibitor |
| Description | Selective cell-permeable MKLP-2 inhibitor. ATPase and Aurora B inhibitor. |
| Product Details | |
|---|---|
| Product Name | Paprotrain |
| Chemical Name | (Z)-2-(1H-Indol-3-yl)-3-pyridin-3-ylprop-2-enenitrile |
| PubChem ID | 12248889 |
| CAS. No. | 57046-73-8 |
| Molecular Formula | C16H11N3 |
| Biological Description | Selective cell-permeable MKLP-2 inhibitor. Reversible ATP-noncompetitive ATPase inhibitor (IC50 values are 1.35 and 0.83 µM for basal and microtubule-stimulated activity respectively). Inhibits Aurora B. Induces cell cycle arrest at early metaphase I. |
| Solubility | Soluble in DMSO to 5 mM |
| Purity | >98% |
| Molecular Weight | 245.28 |
| SMILES | C1=CC=C2C(=C1)C(=CN2)/C(=C/C3=CN=CC=C3)/C#N |
| Source | Synthetic |
| Storage & Handling | |
|---|---|
| Storage Instructions | Store at -20 °C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions. |
| Handling | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20 °C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. |
For research use only. Not intended for any clinical use.