Cat#: CLP-0083
3-(4-Bromophenyl)-3-(trifluoromethyl)-3H-diazirine
Synonyms (s): Probe building block for photoaffinity labeling, Suzuki-Miyaura-compatible multifunctional photo probe building block, Trifluoromethyl diazirine aryl bromide
Empirical Formula (Hill Notation): C8H4BrF3N2
Size: 50 mg
Product Introduction
| Molecular Weight | 265.03 |
| CAS Number | 952143-02-1 |
| Assay | ≥95% (H-NMR) |
| Form | Powder |
| Reaction Suitability | Reagent type: Cross-linking reagent |
| Smiles String | BrC1=CC=C(C2(N=N2)C(F)(F)F)C=C1 |
| Storage Temp. | 2-8 °C |
Application
3-(4-Bromophenyl)-3-(trifluoromethyl)-3H-diazirine is a Suzuki-Miyaura (S−M)-compatible building block tailored for the design of photoaffinity probes (PAPs). Photoaffinity labeling (PAL) is of growing interest in chemical biology and drug discovery research for use in protein profiling; covalent inhibitors; protein-protein interactions and complexes; and target engagement, identification, or validation studies. Diazirines are desirable photoactivable groups for chemical probes; however, their installation is not always straightforward. In response, diazirine-tolerant S-M coupling conditions were developed by Ichiishi, et al, using 3-(4-bromophenyl)-3-(trifluoromethyl)-3H-diazirine and shown to be efficient and scalable with minimal perturbation of the diazirine.
Safety Information
| Storage Class Code | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
For research use only. Not for clinical use.
