Centrosome-related Service for Colon Cancer

Colon cancers are cancers that occur in the large intestine (colon), which typically affect in the elderly. Centrosome abnormality is considered to play a critical role in tumorigenesis as the main cause of chromosome instability. Better understanding of centrosome abnormalities in colon cancer contributes to centrosome-targeting therapeutic development. CD BioSciences provides centrosome-related services in colon cancer with our advanced technology and experienced experts for meeting our global customer's demands in centrosome research and the therapeutic development of colon cancer.

Relevance between Centrosome & Colon Cancers

Centrosome is the major microtubule organizing center (MTOC) In most eukaryotic cells that plays important role in many biological processes, such as generation of microtubules and cell division. It consists of a pair of centrioles surrounded by a mass of proteins and mRNAs, which is called pericentriolar material (PCM). The centrosome abnormality (CA) refers to the centrosome numeric and structural abnormalities, which is frequently observed in colon cancer cells.

Colon cancer involves any epithelial neoplasms, or abnormal growth in the colon tissue. The centrosome abnormalities arise in part from mutations in APC, β-catenin and other genes in colon cancers.

Centrosome regulation in normal cell and colon cancer (Lauren E et al., 2018)

CA is detected as early as low-grade dysplastic lesions of colorectal adenoma to adenocarcinoma sequences. The main centrosome abnormalities include:

• Centrosome positioning defect, including random cytoplasmic locations, scattered, or clustered
• Altered centrosomal protein composition
• Centrosome amplification

In addition to the widely observed numeric and component abnormalities of centrosomes in colon cancer cells, many oncogene and tumor suppressor gene mutations appear to directly impact centrosome structure and activity in colon cancer.

Methods of Centrosome Detection in Colon Cancer

The digital analysis of fluorescence confocal microscopy images is applied to detecting the centrosome abnormalities. Centrosomes are immunofluorescently stained with λ-tubulin, CEP proteins or PCM proteins antibodies. The confocal microscopy is used for capturing images of tissue samples. With developed algorithm, the volume and the quantity are assessed considering the stage of cancer, age of patient, race of patient, the extent of treatment and many other factors.

Our Services

Colon cancers develops from polyps in colon, when the cells grow out of control, colon cancer happens. Centrosome abnormalities are frequently observed in colon cancers as well as other cancers. For assisting our global customers making better progress in the field of centrosome-targeting therapeutic development of colon cancer, as well as the development of diagnosis of its early stage, CD BioSciences offers centrosome-related services as follows.

Why Choose Us

Professional Team

Comprehensive Platform

High Efficiency

One-stop Service

With skilled and experienced genomics and cytology experts, state-of-the-art equipment and advanced technology, CD BioSciences offers customer all over the word services related to fields of centrosomal research. Our one-stop service program is your best assistant to accelerate you process of centrosomal research. Please feel free to contact us and get started with our high-quality services.

Reference

1. Harrison, Lauren E et al. A look into centrosome abnormalities in colon cancer cells, how they arise and how they might be targeted therapeutically. Biochemical pharmacology vol. 147 (2018): 1-8.

Our services are for research use only and not for any clinical use.